Transvection regulates the sex-biased expression of a fly X-linked gene

Enhancer-gene interactions drive split In many species across the animal kingdom, male and female phenotypes differ. One such example is wing spot seen in Drosophila biarmipes flies but not flies. Galouzis Prud'homme investigate X-linked yellow gene its enhancer. Investigating genetics of trait, they found evidence that male-specific phenotype caused by a trans interaction between enhancer silences when it present only one copy (which has single X chromosome) versus two copies female. This thus appears to be regulated differing genomic an phenomenon known as transvection. Science , this issue p. 396